EDUCATION
1972 B.S., Biology, University of Oregon, Eugene
1978 Ph.D., Zoology, University of California-Berkeley
1979-80 Postdoctoral Scholar, Dept. of Biological Sciences, Hopkins Marine Station, Stanford University
1981-85 Postdoctoral Scholar, Developmental Biology, Dept. of Pediatrics, Stanford University, CA.

POSITIONS HELD
1985-91 Assistant Professor, Department of Pathology, University of Wisconsin-Madison
1990-present Member, Comprehensive Cancer Center, University of Wisconsin-Madison
1991-1996 Associate Professor, Department of Pathology , University of Wisconsin-Madison
1993-1996 Director, Graduate Program in Developmental Biology, University of Wisconsin
1996-present Professor, Department of Pathology, University of Wisconsin-Madison
1997-2001 Program Leader, Cell Signaling and Growth Control, Comprehensive Cancer Center, University of Wisconsin-Madison
2003-present Vice Chair for Education, Department of Pathology, University of Wisconsin-Madison

LEADERSHIP ROLES/ADVISORY PANELS
NSF Developmental Biology Review Panel (1989-1993)
Associate Editor, Journal of Cell Science (1991 - 94)
Member, Maternal and Child Health Research Committee, National Institutes of Health, (1994)
Ad hoc member, NIH Pathobiochemistry Study Section (1995, 1996)
Member, NIH Special Review Committee, National Heart, Lung and Blood Institute (1995)
Member, NIH Special Review Committee, National Institute of Diabetes and Digestive and Kidney Disorders (1995)
Advisory Committee, 1996 Proteoglycan Gordon Conference
American Cancer Society Review Panel (1996)
NCI Program Project Site Visit Committee, Mayo Clinic, 1997
Member, NIH Pathobiochemistry Study Section, 1997-2001
NCI Cancer Center Site Visit Committee, Burnham Institute, 1998
Ad hoc member, NCI Initial Review Group, subcommittee A, 1998
NICHHD, Program Project Site Visit Committee, Burnham Institute, 1999
Member, NCI site visit review panel, University of Arkansas for Medical Sciences, 1999
Ad hoc member, NICHHD Initial Review Group, Maternal and Child Health Research Subcommittee, 1999
Advisory Board, Program Project Grant on Regulation of Growth Factor Signaling (A. Lander, PI), Univ. Calif. Irvine. 2001
Extenal Advisory Committee, program on Studies of Monoclonal Gammopathies, Mayo Clinic, 2001-present
NCI Special Emphasis Panel, ZCA1 SRRB-D (2001)
Organizing committee, 2002 Gordon Conference on Proteoglycans, 2001-2002
Editorial Board, Journal of Biological Chemistry, 2002-2007
NCI program project site visit panel, Emory University, 2002
Ad hoc member, NIH Pathobiochemistry study section, June 2002
Organizing Committee, 2004 Annual Meeting, Amercian Society for Matrix Biology
Vice-Chair, Proteoglycan Gordon Conference, 2004
Advisory Council, American Society for Matrix Biology, 2005-2008
Member, NIH Intercellular Interactions (ICI) Special Emphasis Panel, 2005
Chair, Proteoglycan Gordon Conference, 2006
Chair, NIH Intercellular Interactions (ICI) study section, 2006-2008
Advisory Board, International Symposium on Extracellular Glycomatrix in Health and Disease, Awaji, Japan 2006

CURRENT RESEARCH AWARDS
NIH (NCI) Research Grant Award, R01-CA109010 (Rapraeger, PI) 9/1/2004 – 8/31/2009
NIH (NCI) Research Grant Award, R01-CA118839 (Rapraeger, PI) 8/1/2006-7/31/2010
AHA Grant-in-Aid Award (Rapraeger, PI), 7/1/2006-6/30/2008
Draper Fund Award (Rapraeger, PI) 7/1/2006-6/30/2007
NIH (NIAMS) Conference Grant, 12th Gordon Conference on Proteoglycans (Rapraeger, PI) 7/1/2006-6/30/2007

MEMBERSHIP IN TRAINING PROGRAMS
Cellular and Molecular Pathology Graduate Program
Oncology Graduate Program
Molecular and Cellular Pharmacology Graduate Program
Cellular and Molecular Biology Graduate Program
MD/PhD Training Program
Surgical Oncology Training Program

RECENT PUBLICATIONS:
• Rapraeger, A.C. (2001). Molecular interactions of syndecans during development. Seminars in Cell and Dev. Biol. 12:107-116.
• Allen, B.L, Filla, M. and Rapraeger, A.C. (2001). Role of heparan sulfate as a tissue specific regulator of FGF4 and FGF receptor recognition. J. Cell Biol., 155: 845-857.
• Cornelison, D.D.W., Filla, M., Stanley, H., Rapraeger, A.C. and B.B. Olwin (2001). Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Dev. Biol. 239: 79-94.
• Rapraeger, A.C. (2002). Heparan sulfate-growth factor interactions. Meth. Cell Biol. 69: 83-109.
• Beauvais, D. and Rapraeger, A.C. (2003). Syndecan-1 mediated cell spreading requires signaling by v3 integrins in human mammary carcinoma cells. Exp. Cell Res. 286: 219-232.
• Burbach, B.J., Friedl, A., Mundhenke, C. and Rapraeger, A.C. (2003). Syndecan-1 accumulates in the lysosomes of poorly differentiated breast carcinoma cells. Matrix Biol., 22: 163-177.
• McQuade, K.J. and Rapraeger, A.C. (2003). Syndecan transmembrane and extracellular domains have unique and distinct roles in cell spreading. J. Biol. Chem., 278: 46607-46615.
• Motamed, K., Blake, D.J., Angello, J.G., Allen, B.L., Rapraeger, A.C., Hauschka, S.D. and Sage, E.H. (2003). Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A. J. Cell. Biochem., 90: 408-423.
• Allen, B.L. and Rapraeger, A.C. (2003). Spatial and temporal expression of distinct heparan sulfate domains in mouse development regulate FGF and FGF receptor complex assembly. J. Cell Biol., 163: 637-648.
• Beauvais, D.B. and Rapraeger, A.C. (2004). Syndecans in tumor cell adhesion and signaling. Reprod. Biol. Endocrin., 2:3 (http://www.rbej.com/content/2/1/3)
• Griffith, R.B., Allen, B.L., Rapraeger, A.C. and Kiessling, L.L (2004). A polymer scaffold for protein oligomerization. J. Amer. Chem. Soc., 126(6):1608-1609.
• Beauvais, D.M., Burbach, B.J. and Rapraeger, A.C. (2004). The syndecan-1 ectodomain regulates αv3 integrin activity on human mammary carcinoma cells. J. Cell Biol., 167: 171-181.
• Cornelison, D.D.W., Wilcox-Adelman, S.A., Goetinck, P.F., Rauvala, H., Rapraeger, A.C. and Olwin, B.B. (2004). Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Genes & Dev. 18: 2231-2236.
• Burbach, B.J. and Rapraeger, A.C. (2004). Syndecan-1 ectodomain regulates matrix-dependent signaling on mammary carcinoma cells. Exp. Cell Res., 300: 234-237.
• Jasuja, R., Papanno, W. N., Allen, B.L., Rapraeger, A.C. and Greenspan, D. S. (2004). Cell surface heparan sulfate proteoglycans potentiate chordin’s antagonism of BMP signaling and are necessary for cellular uptake of chordin. J. Biol. Chem., 279: 51289-97.
• Whitworth, M.K., Backen, A.C., Clamp, A., Wilson, G., McVey, R., Friedl, A., Rapraeger, A., David, G., McGown, A., Slade, R.J., Gallagher, J.T. and Jayson, G.C. (2005). Regulation of FGF2 activity by human ovarian cancer tumor endothelium. Clinical Cancer Res., 11:4282-4287.
• Dai, Y., Yang, Y., MacLeod, V., Yue, X., Rapraeger, A.C., Shriver, Z., Venkataraman, G.,Sasisekharan, R., and Sanderson, R.D. (2005). HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J. Biol. Chem., 280: 40066-40073.
• McQuade, K.J., Beauvais, D.M., Burbach, B.J. and Rapraeger, A.C. (2006). Syndecan-1 core protein regulates v5-integrin activity in B82L fibroblasts. J. Cell Sci., 119: 2445-2456.
• Jastrebova, N., Vanwildemeersch, M., Rapraeger, A.C. , Giménez-Gallego, G., Lindahl, U., and Spillmann, D. (2006). Heparan Sulfate-Related Oligosaccharides in Ternary Complex Formation with Fibroblast Growth Factors 1 and 2 and Their Receptors. J. Biol. Chem., in press.
• Ma, P., Beck, S., Raab, R., Robert McKown, R., George Coffman, G., William J. Chirico, W.J., Rapraeger, A.C. and Laurie, G.W. (2006). Deglycosylation of coreceptor syndecan-1 is required for core protein binding of epithelial-restricted mitogen ‘lacritin’. J. Cell Biol., in press.