The major research interest of this laboratory is to study the pathogenic mechanism underlying Alzheimer’s disease, to look for the biomarkers for the early AD diagnosis and to search for the potential therapeutics that can stop or delay the pathogenic process at the early stage of AD development.

Currently, we are focus on:
1) the possible effect of oxidative damage of Aß-degrading enzymes on the accumulation of Aß in AD brain;
2) the potential biological significance of tissue transglutaminase on the abnormal protein crosslinking seen extensively in AD pathology.

In addition, this laboratory is also interested in the general biological function of pleckstrin homology (PH) domain in signal transduction. We are particularly interested in those PH-DH domain-containing oncoprotein and their potential interacting molecules under certain pathophysiological conditions such as cancer and neurodegenerative diseases.