Class will include an introductory lecture into
the topic that the class will discuss the following
week and
the assignment of papers to be read for that discussion.
Students will come to class the next week having
read the papers and answered some questions geared
to understanding the paper.
Grading will be based on class participation.
Students requiring additional credit can enroll
for independent
study and complete a written paper.
| Sept. 8 |
|
NO CLASS |
| |
| Sept. 15 |
|
INTRODUCTION: |
Molecular Aspects of Integrin Activation |
| |
|
Reading for Sept. 22: |
| |
|
Kim et al (2003). Science 301: 1720-1725. |
| |
|
Tadakoro et al (2003). Science 302: 103-106. |
| |
|
Questions for discussion papers |
| |
| Sept. 22 |
|
DISCUSSION: |
Molecular Aspects of Integrin Activation |
| |
|
INTRODUCTION: |
Integrin Activation of Downstream Signaling |
| |
|
Reading for Oct 6: |
| |
|
Blystone
et al. (1997). J. Biol. Chem. 272: 28757-28761. |
| |
|
Butler et
al. (2003). J. Biol. Chem. 278: 5264-5270. |
| |
|
Gao et al.
(2005). J. Biol. Chem. 280: 15422-15429. |
| |
|
Questions
for discussion papers |
| |
| Sept. 29 |
|
NO CLASS -- MCP graduate student research symposium |
| |
| Oct. 6 |
|
DISCUSSION: |
Integrin Activation
of Downstream Signaling. |
| |
|
INTRODUCTION: |
Signaling Pathways to
the Cytoskeleton/ Cell Cycle |
| |
|
Reading
for Oct. 13: |
| |
|
Roovers
et al. (1999) Mol. Biol. Cell 10: 3197-3204. |
| |
|
Mettouchi
et al (2001) Mol. Cell 8: 115-127. |
| |
|
Questions
for discussion papers |
| |
| Oct. 13 |
|
DISCUSSION: |
Signaling Pathways to the Cytoskeleton/Cell Cycle |
| |
|
INTRODUCTION: |
MT1-MMP and Tumor Traffic in 3D Matrix |
| |
|
Reading for Oct. 20: |
| |
|
Hotary
et al (2003). CELL 114: 33-45. |
| |
|
Questions
for discussion papers |
| |
| Oct. 27 |
|
DISCUSSION: |
MT1-MMP and Tumor Traffic in 3D Matrix |
| |
|
INTRODUCTION: |
Mammary Acinar Morphogenesis |
| |
|
Reading for Nov. 3: |
| |
|
Brugge
et al. (2002). CELL 111:20-40. |
| |
|
Brugge
et al. (2005). MCB 25:4591-4601. |
| |
|
Questions
for discussion papers |
| |
| Nov. 3 |
|
DISCUSSION: |
Mammary Acinar Morphogenesis |
| |
|
INTRODUCTION: |
Mammary Carcinoma Invasion |
| |
|
Reading for Nov. 10: |
| |
|
Radisky
et al. (2005) Nature 436:123-127 |
| |
|
Liu
et al. (2004) JCB 164:603-612 |
| |
|
Questions
for discussion papers |
| |
| Nov. 10 |
|
DISCUSSION: |
Mammary Carcinoma Invasion |
| |
|
INTRODUCTION: |
Heparan Sulfate Regulation of Growth Factor Signaling |
| |
|
Reading for Nov. 17: |
| |
|
Emerson
(2004) |
| |
|
Lai
et al. (2003) |
| |
|
Questions
for discussion papers |
| |
| Nov. 17 |
|
DISCUSSION: |
Heparan Sulfate Regulation of Growth Factor Signaling |
| |
|
INTRODUCTION: |
Gene regulation of the Angiogenic Phenotype |
| |
|
Reading for Dec 1: |
| |
|
Myers
et al (2000) |
| |
|
Boudreau
et al (1997) |
| |
|
Myers
et al (2002) |
| |
|
Questions
for discussion papers |
| |
| Nov. 24 |
|
NO CLASS -- Thanksgiving |
| |
| Dec. 1 |
|
DISCUSSION: |
Gene Regulation of the Angiogenic Phenotype |
| |
|
INTRODUCTION: |
Integrin Signaling During
Angiogenesis |
| |
|
Reading
for Dec. 8: |
| |
|
Reynolds
et al (2002) |
| |
|
Hood
et al (2003) |
| |
| Dec. 8 |
|
DISCUSSION: |
Integrin Signaling During Angiogenesis. |
| |
|
INTRODUCTION: |
Endogenous Inhibitors Of Tumor Angiogenesis |
| |
|
Reading for Dec. 15: |
| |
|
Mongiat
et al (2003) |
| |
|
Hamano
et al (2003) |
| |
| Dec. 15 |
|
DISCUSSION: |
Endogenous Inhibitors of Tumor Angiogenesis |
Education