Portrait of Andreas Friedl, MD


CONTACT INFORMATION
Office:
3158 MFCB
Phone:
(608) 265-4262
Fax:
(608) 265-3301
Pager:
(608) 265-7000 6009
Mailing Address:

3158 MFCB
1685 Highland Ave
Madison, WI 53705

Andreas Friedl, MD

  • Professor
  • Department Chair

Department of Pathology and Laboratory Medicine



Education
1993 -
1995
Postdoctoral Fellowship, University of Wisconsin, Madison, WI
1989 -
1993
Residency in Anatomic and Clinical Pathology, University of Wisconsin, Madison, WI
1987
Dr. of Medicine (Dr. med.), University of Erlangen, Germany
1985
MD, University of Erlangen, Germany

Research Interests
Tumor-stroma interactions; heparan sulfate proteoglycans as modulators of growth factors in human disease; tumor angiogenesis
Detail:

My research focuses on the role of heparan sulfate proteoglycans (HSPGs) in loss of growth control in cancer. HSPGs are hybrid molecules, which consist of core proteins and heparin-like polysaccharide domains. HSPGs are found in abundance on cell surfaces and in the extracellular matrix.

Specifically, we study the regulation of fibroblast growth factor (FGF) signaling by HSPGs. HSPGs modulate binding of FGFs to their tyrosine kinase receptors and consequently signaling. My laboratory investigates the hypothesis that HSPG alterations contribute to loss of growth control in cancer by modulating the FGF signaling pathway. Recently, we have identified the HSPG glypican-1 as a specific stimulator of FGF2-induced angiogenesis in gliomas.

Another ongoing project examines the role of the cell surface HSPG syndecan-1 in epithelial-stromal interactions in breast carcinomas. We found that syndecan-1 is induced in the stromal fibroblasts of breast carcinomas, mimicking the mesenchymal expression of this molecule during development. Stromal syndecan-1 participates in a reciprocal feedback loop, which stimulates carcinoma cell growth via angiogenesis-dependent and independent mechanisms.


Clinical Interests
Surgical pathology, Pathology of the breast, Medical diseases of the kidney
Detail:
A second more clinically applied research effort aims at developing techniques to measure activities of anti-cancer agents in tissue samples. As part of the Experimental Therapeutics program of the University of Wisconsin Comprehensive Cancer Center, we are investigating new biologic endpoints and surrogate markers for anti-angiogenic and other treatments.

Appointments & Positions
2011 -
Present
Chair, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI
2007 -
Present
Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
2000 -
Present
Staff Pathologist, William S. Middleton Memorial Veterans Hospital, Madison, WI
2005 -
2011
Director, Surgical Pathology, University of Wisconsin Hospital and Clinics, Madison, WI
2003 -
2007
Associate Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
1997 -
2003
Assistant Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
1985 -
1986
Military Service: Captain, medical corps in Hemau, West Germany

Certifications & Licensure
1990 -
Present
Wisconsin Medical License
1993 -
Present
Board Certification in Anatomic and Clinical Pathology

Awards & Honors
2000
American Cancer Society - Research Scholar
1993
Physician's Research Training Award by the American Cancer Society
1992
Chief Resident
1987
"Doctor of Medicine", Magna Cum Laude
1987
Scholarship from "German Research Association"
1978
"Bavarian Scholarship for Gifted Students"

Societies & Memberships
2011 -
Present
Association of Pathology Chairs (APC)
2001 -
Present
American Association for Cancer Research
2006 -
2011
Association of Directors of Anatomic and Surgical Pathology
1997 -
Present
United States and Canadian Academy of Pathology
2001 -
2010
Renal Pathology Society

Selected Publications