Portrait of Donna Peters, PhD


CONTACT INFORMATION
Office:
6590 MSC
Phone:
(608) 262-4626
Fax:
(608) 265-3153
Mailing Address:

6590 MSC
1300 University Ave
Madison, WI 53706

Donna Peters, PhD

  • Professor

Department of Pathology and Laboratory Medicine



Education
1980 -
1983
Postgraduate Training, Albert Einstein College of Medicine
1976 -
1981
PhD, Rutgers University, New Brunswick, New Jersey
1972 -
1976
BA, Douglass College, New Brunswick, New Jersey

Research Interests

Cell-matrix signaling in the human eye; glaucoma

Detail:

It is well established that a number of signal transduction events that govern both normal and abnormal cell behavior are modulated by interactions between cells and their extracellular matrix. The significance of these cell-matrix interactions and the signal transduction pathways regulated by them is clearly illustrated by the diversity and importance of biological processes controlled by them. Among these biological processes are gene expression, cell growth, apoptosis, differentiation, adhesion, cell migration, and cell contractility.

My laboratory is studying the role of cell-matrix interactions in the anterior chamber of the human eye so that we can better understand the cause of glaucoma. Glaucoma is an eye disease that is known to be the world's second leading cause of blindness. It is believed to be a defect in mechanochemical signaling events that serve to maintain normal levels of intraocular fluid in the anterior chamber of the eye.

My laboratory is interested in understanding what types of cell-matrix interactions occur in the anterior chamber of the human eye and the types of signal transduction events that they control. Recent studies in my laboratory have shown that interactions with an extracellular matrix protein called fibronectin help modulate the levels of intraocular pressure in the human eye and the movement of fluid through the anterior chamber. We have identified the domain in fibronectin that regulates intraocular pressure and at least two signaling molecules whose function is controlled by this domain. We are currently looking for the receptor that interacts with this domain and are characterizing the components of the signaling pathways and the biological processes governed by this interaction. Our long-term goal is to identify potential extracellular and intracellular targets that can be used to control glaucoma via genetic approaches such as gene therapy.


Appointments & Positions
2005 -
Present
Professor (Affiliate Appt), Department of Ophthalmology & Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
2005 -
Present
Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
1993 -
2005
Assistant Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
1986 -
1993
Assistant Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
1984 -
1986
Assistant Scientist, Department of Medicine, University of Wisconsin- School of Medicine Madison, WI
1983 -
1984
Project Associate, Department of Medicine, University of Wisconsin School of Medicine, Madison, WI

Selected Publications
Clark R, Nosie A, Walker T, et al. "Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells." Mol. Cell Proteomics. 2013;12(1):194-206.
Filla MS, Schwinn MK, Nosie AK, Clark RW, Peters DM. "Dexamethasone-associated cross-linked actin network formation in human trabecular meshwork cells involves β3 integrin signaling." Invest. Ophthalmol. Vis. Sci.. 2011;52(6):2952-9.
Faralli JA, Newman JR, Sheibani N, Dedhar S, Peters DM. "Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells." Invest. Ophthalmol. Vis. Sci.. 2011;52(3):1684-92.