CONTACT INFORMATION
Office:
K4/432 CSC
Phone:
(608) 263-0057
Fax:
(608) 265-6215
Mailing Address:

Box 8550 Clinical Science Center
600 Highland Avenue
Madison, WI 53792

Erik Ranheim, MD, PhD

  • Professor (CHS)
  • Vice Chair of Education

Department of Pathology and Laboratory Medicine



Education
1999
Hematopathology Fellowship, Stanford University
1998
Anatomic Pathology Residency, Stanford University
1996
MD, University of Minnesota
1994
PhD, University of Minnesota

Research Interests

Beta-catenin in normal and neoplastic lymphoid development; tumor immunology; hematopoietic and leukemic stem cell biology

Detail:

Dr. Ranheim's laboratory has two broad areas of interest, the interaction of the immune system with tumor cells, and the role of the frizzled/wnt/beta-catenin pathway in normal and neoplastic lymphoid development and function. The field of tumor immunology is replete with studies showing that immunization of mice prior to tumor introduction can prevent cancer. While this demonstrates the potential of the immune system in treating cancer, it says almost nothing about the true clinical situation of a patient with a long standing tumor presenting for treatment. He hopes to step back and examine the mechanisms of how the immune system and tumor interact and why, even with evidence that anti-tumor lymphocytes are present, the tumor usually wins. Dr. Ranheim is involved in anti-tumor immunity research in both mouse models and human patients in B cell leukemia/lymphoma and melanoma, in collaboration with other members of the UW Carbone Cancer Center.

The second area of interest involves the frizzled/wnt pathway, a family of receptors and ligands that regulate the level of beta-catenin within cells that has been implicated in a number of human tumors, most notably colon cancer and the familial polyposis syndrome. His interest stems from the fact that work in Irv Weissman’s laboratory showed that beta-catenin signaling may be a critical signal directing hematopoietic stem cells to self-renew rather than differentiate. His examination of frizzled 9 knockout mice suggests that this pathway may offer a similar signal to developing cells in the B lymphoid lineage as well as affecting plasma cell function. Malignant cells also seem to be signaled to "self-renew" rather than differentiate, and the beta-catenin pathway is likely to be involved in this decision. Dr. Ranheim’s laboratory has found that particular members of this signaling pathway are critical for development of lymphoma/leukemia in a mouse model of human chronic lymphocytic leukemia and is exploring whether other B cell malignancies may also use this pathway to enhance survival and growth of the malignant cells.


Clinical Interests
Hematopathology, with a particular interest in chronic lymphocytic leukemia and other B cell malignancies.

Appointments & Positions
2012 -
Present
Vice Chair for Education, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI
2010 -
Present
Associate Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School and Public Health, Madison, WI
2007 -
Present
Residency Program Director, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI
2003 -
2010
Assistant Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School and Public Health, Madison, WI
1999 -
2003
Staff Physician, Hematopathology, Stanford University School of Medicine

Certifications & Licensure
Anatomic Pathology
Hematopathology
WI License

Awards & Honors
2014
Dean's Teaching Award, University of Wisconsin-Madison School of Medicine and Public Health
2013
Reza Award for Excellence in Teaching, University of Wisconsin-Madison School of Medicine and Public Health Dept of Pathology
2012
Top Doctor, Pathology and Community Service, Madison Magazine
2011
Physician Citizen of the Year, Wisconsin Medical Society
1995
Alpha Omega Alpha
1988
Phi Beta Kappa

Societies & Memberships
American Society of Hematology
Society of Hematopathology
USCAP

Selected Publications