CONTACT INFORMATION
Office:
5468 MSC
Phone:
(608) 265-8715
Mailing Address:

5468 MSC
1300 University Ave
Madison, WI 53706

Matyas Sandor, PhD

  • Professor

Department of Pathology and Laboratory Medicine



Education
1981 -
1986
University of Iowa
1980 -
1981
Postgraduate Training, NCI, NIH
1979
PhD, L. Eotvos University of Sciences

Research Interests

Immune responses to infectious disease

Detail:

We study the role of T cells in granulomatous immune responses induced by various infectious agents including Schistosoma mansoni, Leishmania donovani and Mycobacterium bovis. Granulomas are localized inflammatory reactions in which both T cells and the infectious agents are colocalized in the lesion. Granulomas protect the host against infection but can also cause diseases such as sarcoidosis or Crohn's disease. Using T cells from TCR transgenic mice as a source of monoclonal T cells of known antigen specificity and infectious agents that are transfected with the same antigenic epitope recognized by the TCR transgene we examine how T cells fight chronic infections. We are also interested in how different T cells work together. We study how antibodies and antibody associated effector pathways mediated by complement and Fc receptors interfere with T cell responses. We hope our studies will contibute to the creation of better vaccines and better treatments for granulomatous diseases.


Selected Publications
Clarkson BD, Héninger E, Harris MG, Lee JE, Sandor M, Fabry Z. "Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS." Adv. Exp. Med. Biol.. 2012;946:309-33.
Schreiber HA, Sandor M. "Monocyte-derived inflammatory dendritic cells in the granuloma during mycobacterial infection." Adv. Exp. Med. Biol.. 2012;946:277-93.