CONTACT INFORMATION
Office:
5468 MSC
Phone:
(608) 265-8715
Mailing Address:

5468 MSC
1300 University Ave
Madison, WI 53706

Matyas Sandor, PhD

  • Professor

Department of Pathology and Laboratory Medicine



Education
1981 -
1986
University of Iowa
1980 -
1981
Postgraduate Training, NCI, NIH
1979
PhD, L. Eotvos University of Sciences

Research Interests

Immune responses to infectious disease

Detail:

We study the role of T cells in granulomatous immune responses induced by various infectious agents including Schistosoma mansoni, Leishmania donovani and Mycobacterium bovis. Granulomas are localized inflammatory reactions in which both T cells and the infectious agents are colocalized in the lesion. Granulomas protect the host against infection but can also cause diseases such as sarcoidosis or Crohn's disease. Using T cells from TCR transgenic mice as a source of monoclonal T cells of known antigen specificity and infectious agents that are transfected with the same antigenic epitope recognized by the TCR transgene we examine how T cells fight chronic infections. We are also interested in how different T cells work together. We study how antibodies and antibody associated effector pathways mediated by complement and Fc receptors interfere with T cell responses. We hope our studies will contibute to the creation of better vaccines and better treatments for granulomatous diseases.


Selected Publications
Schreiber HA, Sandor M. "Monocyte-derived inflammatory dendritic cells in the granuloma during mycobacterial infection." Adv. Exp. Med. Biol.. 2012;946:277-93.
Clarkson BD, Héninger E, Harris MG, Lee JE, Sandor M, Fabry Z. "Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS." Adv. Exp. Med. Biol.. 2012;946:309-33.