CONTACT INFORMATION
Office:
L5/182 CSC
Phone:
(608) 265-6069
Pager:
(608) 265-7000 #3225
Mailing Address:

L5/182 CSC-8550
600 Highland Ave
Madison, WI 53792-8550

Weixiong Zhong, MD, PhD

  • Associate Professor

Department of Pathology and Laboratory Medicine



Education
1995
PhD, University of Iowa, Iowa City, IA
1982
MD, Sun Yat-Sen University of Medical Sciences, China

Research Interests

Molecular mechanisms of selenium in prostate cancer chemoprevention; oxidative stress and redox regulation in carcinogenesis

Detail:

Research in my laboratory focuses on understanding the molecular mechanisms of selenium in cancer chemoprevention and the role of reactive oxygen species in carcinogenesis. Selenium is an essential trance element for human health. Selenium deficiency is known to be linked to the risk of certain cancers. Recent clinical studies demonstrated that selenium is a promising chemopreventive agent for prostate and colon cancers. We are currently studying redox-mediated and epigenetic effects of selenium on cell cycle and apoptosis in human prostate cancer cells. We are interested in determining how selenium modulates intracellular redox state, DNA methylation, and histone protein modifications to regulate the expression of genes involved in protection against oxidative stress, tumor suppression, cell cycle, and apoptosis. We also study combinations of selenium with other dietary chemopreventive agents, DNA methylation inhibitors, and histone deacetylase inhibitors for maximizing cancer prevention and minimizing the side effects of individual agents.


Clinical Interests
Renal Pathology. Genitourinary Pathology.

Appointments & Positions
2008 -
Present
Associate Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
2002 -
Present
Staff Pathologist, Pathology and Laboratory Medicine Service, William S. Middleton Memorial Veterans Hospital
2002 -
2008
Assistant Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
2000 -
2002
Instructor, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
1999 -
2000
Surgical Pathology Fellow, focusing on renal pathology, Department of Pathology, University of Wisconsin Hospital and Clinics
2000
Research Associate, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
1990 -
1995
Research Assistant, free Radical and Radiation Biology Program, University of Iowa
1987 -
1989
Visiting Research Fellow, Department of Neurology, College of Medicine, University of Iowa
1982 -
1986
Instructor, Department of Histology and Embryology, Guangdong Medical and Pharmaceutical College, Guangzhou, China

Selected Publications
Chaiswing L, Zhong W, Liang Y, Jones DP, Oberley TD. "Regulation of prostate cancer cell invasion by modulation of extra- and intracellular redox balance." Free Radic. Biol. Med.. 2012;52(2):452-61.
Bin Hafeez B, Zhong W, Mustafa A, Fischer JW, Witkowsky O, Verma AK. "Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCĪµ, Stat3 and neuroendocrine markers." Carcinogenesis. 2012;33(12):2586-92.