5468 MSC
(608) 265-8715
Mailing Address:

5468 MSC
1300 University Ave
Madison, WI 53706

Matyas Sandor, PhD

  • Professor

Department of Pathology and Laboratory Medicine

1981 -
University of Iowa
1980 -
Postgraduate Training, NCI, NIH
PhD, L. Eotvos University of Sciences

Research Interests

Immune responses to infectious disease


We study the role of T cells in granulomatous immune responses induced by various infectious agents including Schistosoma mansoni, Leishmania donovani and Mycobacterium bovis. Granulomas are localized inflammatory reactions in which both T cells and the infectious agents are colocalized in the lesion. Granulomas protect the host against infection but can also cause diseases such as sarcoidosis or Crohn's disease. Using T cells from TCR transgenic mice as a source of monoclonal T cells of known antigen specificity and infectious agents that are transfected with the same antigenic epitope recognized by the TCR transgene we examine how T cells fight chronic infections. We are also interested in how different T cells work together. We study how antibodies and antibody associated effector pathways mediated by complement and Fc receptors interfere with T cell responses. We hope our studies will contibute to the creation of better vaccines and better treatments for granulomatous diseases.

Selected Publications
Harding JS, Schreiber HA, Sandor M. "Granuloma transplantation: an approach to study mycobacterium-host interactions." Front Microbiol. 2011;2:245.
Carrithers LM, Hulseberg P, Sandor M, Carrithers MD. "The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations." FEMS Immunol. Med. Microbiol.. 2011;63(3):319-27.