CONTACT INFORMATION
Office:
Rm 5533, Wisconsin Institute for Medical Research (WIMR II)
Phone:
608-263-1227
Mailing Address:

1111 Highland Avenue
Madison, WI 53705

Subhojit Roy, MD, PhD

  • The UW Medical Foundation (UWMF) Professor of Pathology & Laboratory Medicine

Department of Pathology and Laboratory Medicine



Education
2005 -
2007
Postdoctoral Fellow, Center for Neurodegenerative Diseases Research (CNDR) University of Pennsylvania, Philadelphia, PA
2001 -
2006
Residency/Neuropathology fellowship in Neuropathology, Hospital of the University of Pennsylvania, Philadelphia, PA
1997 -
2001
PhD in Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia

Research Interests

Cell Biology of neuronal trafficking in physiology and neurodegenerative diseases

Detail:

Cell Biology of neuronal trafficking in physiology and neurodegenerative diseases. The Roy lab is interested in the cell biology of neuronal trafficking in physiology and disease. A general approach in the lab is to develop simple cellular models of normal and abnormal biological phenotypes – using dissociated neurons, 3-D organoids, and induced pluripotent stem cells (iPSC's) – and test predictions from these models in brains. For a list of publications, please see: http://www.roylab.org/publications.html. Current projects include novel uses of CRISPR-Cas9 technology in cellular model-systems of neurodegenerative diseases, optogenetic approaches to study slow axonal transport, and use of iPSC’s to explore human cell biology. The lab has ongoing collaborations with researchers at the Wisconsin Institute for Discovery (WID), the Waisman Center, and other investigators at UW-Madison; and is located on modern, state of the art laboratory and office space overlooking lake Mendota (within the Wisconsin Institute for Medical Research or WIMR-II tower: WIMR-II-science-without-walls).


Clinical Interests
Neuropathology

Appointments & Positions
2016 -
Present
Affiliate Professor, Department of Neuroscience, UW-Madison
2016 -
Present
Professor, Department of Pathology and Laboratory Medicine, UW-Madison
2016 -
Present
Director of Neuropathology core, Wisconsin Alzheimer’s center
2013 -
2016
Associate Professor, Departments of Pathology and Neurosciences, University of California, San Diego
2011 -
2016
Attending Neuropathologist, University of California Hospitals (Thornton, Hillcrest)
2009 -
2016
Attending Neuropathologist, Veterans Affairs Hospital, San Diego
2008 -
2013
Assistant Professor, Departments of Pathology and Neurosciences, University of California, San Diego

Awards & Honors
2016
UW Medical Foundation professorship
2011
American Federation for Aging Research
2011
John S Spice award in aging from the Larry Hillblom Foundation
2010
March of Dimes Basil O’ Connor Scholar
2009
American Parkinson’s disease Scholar
2008
New Investigator award, Alzheimer’s Association

Selected Publications
Wang L, Das U, Scott DA, Tang Y, McLean PJ, Roy S. "α-synuclein multimers cluster synaptic vesicles and attenuate recycling." Curr. Biol.. 2014;24(19):2319-26.
Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. "Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway." Neuron. 2013;79(3):447-60.
A G, Y T, L W, et al. "A dynamic formin-dependent deep F-actin network in axons." Journal of Cell Biology. 2015;210(3):401-417.
R S, ML C, MP B, et al. "Patches of disorganization in the neocortex of children with autism." N Engl J Med. 2014;370(13):1209-1219.
Ganguly A, Roy S. "Using photoactivatable GFP to track axonal transport kinetics." Methods Mol. Biol.. 2014;1148:203-15.