CONTACT INFORMATION
Office:
217 Bascom Hall
Phone:
608-262-2433
Mailing Address:

217 Bascom Hall
500 Lincoln Dr.
Madison, WI 53706

DEPARTMENT AFFILIATIONS

William J. Karpus, PhD

  • Professor
  • Dean of the Graduate School

Department of Pathology and Laboratory Medicine



Education
1991 -
1994
Postdoctoral Fellowship, Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine (NUFSM), Chicago, IL
1987 -
1991
Ph.D., Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI; Minor: Biochemistry
1980 -
1984
B.S., Department of Biology, Michigan Technological University, Houghton, MI; Major: Biological Sciences

Research Interests
Detail:

I have been studying the role of chemokines in experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) for 21 years and have been using rat and mouse models of MS to understand demyelinating disease pathogenesis for the past 29 years. We have identified key chemokines and receptors in the regulation of T cell and macrophage migration and function using a variety of approaches including neutralizing antibody treatment and mice deficient for select chemokine ligands or receptors. These studies have identified significant roles for a subset of chemokines and chemokine receptors in EAE pathogenesis and point to these factors as potential therapeutic targets for MS. More recently, we have observed a role for Delta Like Ligand-mediated Notch signaling in the regulation of chemokine receptor cell surface expression in the control of T cell migration to the central nervous system (CNS). Additionally, we have considerable experience investigating mechanisms of immunologic tolerance in CNS demyelinating diseases as an approach for antigen-specific therapy. The current project will determine mechanisms of chemokine regulation that control lymphocyte entry into the brain and identify new drug targets for relapsing MS therapy.


Appointments & Positions
2015 -
Present
Dean of the Graduate School, University of Wisconsin-Madison
2015 -
Present
Professor, Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison
2012 -
2015
Associate Dean for Student Affairs, The Graduate School, Northwestern University
2006 -
2015
Professor (with tenure), Departments Pathology (primary appointment) and Microbiology-Immunology (secondary appointment), NUFSM
2001 -
2015
Associate Professor (with tenure), Department of Pathology and Department of Microbiology-Immunology (secondary appointment), NUFSM
2000 -
2015
Graduate faculty member, Northwestern University (NU), Evanston, IL
2008 -
2012
Director, Walter S. and Lucienne Driskill Graduate Training Program in Life Science (formerly, Integrated Graduate Program in the Life Sciences, IGP), NUFSM
1999 -
2001
Assistant Professor (secondary appointment), Department of Microbiology-Immunology, NUFSM
1996 -
2001
Assistant Professor, Department of Pathology, NUFSM
1994 -
1996
Research Assistant Professor, Department of Microbiology and Immunology, NUFSM

Awards & Honors
2008
Veterans Administration visiting scientist, Portland VA Medical Center
2006
(Through 2012) - Marie A. Fleming Research Professor, Department of Pathology, Northwestern University
2004
Veterans Administration visiting scientist, Portland VA Medical Center
2001
Dolph Adams Award (Most Cited Paper in Journal of Leukocyte Biology), Society for Leukocyte Biology
1992
(Through 1994) - National Research Service Award, NINDS, NIH (NS 09131)
1991
(Through 1994) - National Multiple Sclerosis Society, Postdoctoral Fellowship Grant (FG-934)
1987
(Through 1988) - Thomas C. Rumble Fellowship, Wayne State University, Detroit, MI
1986
(Through 1987) - Marquette University Fellowship, Marquette University, Milwaukee, WI

Societies & Memberships
2010 -
Present
Society for Leukocyte Biology
2000 -
Present
American Association for Investigative Pathology
1995 -
Present
New York Academy of Sciences
1994 -
Present
International Society for Neuroimmunology
1993 -
Present
American Association of Immunologists
1990 -
Present
Sigma Xi

Selected Publications